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. 2020 Jul 16;18(9):2224–2235. doi: 10.1038/s41423-020-0500-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Bindarit administration alleviates periodontal inflammation in DP mice. a The levels of various inflammatory cytokines in the periodontium of bindarit-treated and vehicle-treated DP mice on day 28 after ligature removal were analyzed by LEGENDplex^TM bead-based immunoassays (n = 6 per group). Error bars indicate SEM. *p < 0.05 (unpaired two-tailed Student’s t test). b The mRNA expression levels of inflammatory cytokines in the periodontium of each group on day 28 after ligature removal were analyzed by RT-qPCR (n = 6 per group). Error bars indicate SEM. *p < 0.05 (unpaired two-tailed Student’s t test). c IL-1β and TNF-α expression levels in the periodontium of each group on day 28 after ligature removal were measured by IF staining. Nuclei were stained with DAPI. Scale bar = 25 μm. d IL-1β and TNF-α levels in the periodontium of each group (n = 6 per group) on day 28 after ligature removal were measured by western blotting. *p < 0.05 (unpaired two-tailed Student’s t test).