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. 2021 Aug 11;18(9):2188–2198. doi: 10.1038/s41423-021-00749-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Cellular kinetics of MPTK- and MTK-CAR-T cells in vivo. A–C In vivo expansion and persistence of MPTK-CAR-T cells in peripheral blood or pericardial effusion from three patients. D–G The expansion and persistence of MPTK-CAR-T cells in CRL5826-PD-L1 tumor-bearing NPG mice. Tumor growth (D), and PB analysis of the proportions of human CD45-positive cells (E), human CD3-positive cells (F) and human TCR-positive cells (G) after CAR-T cell intravenous injection (n = 5 animals per group)