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. 2021 Jul 8;46(11):2000–2010. doi: 10.1038/s41386-021-01091-6

Fig. 5. Systemic administration of CP-94,253 normalizes the global behavioral profile of all ASD models.

Fig. 5

A PCA of sociability and control assay data from ASD model mice following vehicle treatment (individual models are color coded). B PCA of control (black) and ASD model (red) mice following vehicle treatment. C PCA of control (black) and ASD model (red) mice following CP-94,253 treatment. Individual data points shown, dashed lines represent 95th % quantile intervals. D Representative example of Euclidean distance calculation to control average following systemic administration of either vehicle or CP-94,253 in a Sert-Cre+/–:16p11.2flx/flx mouse. E Quantification of the Euclidean distance to the center of the control group for each mouse following systemic administration of either vehicle or CP-94,253 (F1,209 = 285.5, P < 0.0001, n = 105–106). If error bars are not clearly visible, they are smaller than the symbol used to represent the SEM. Data are mean ± SEM. ***P < 0.001; two-way ANOVA with Sidak’s multiple comparison post hoc test.