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. 2021 Sep 9;11:18007. doi: 10.1038/s41598-021-97390-5

Figure 1.

Figure 1

Comparison of CXCL10 mRNA expression between DCIS and invasive carcinoma. (A) CXCL10 mRNA expression is significantly higher in invasive carcinoma than in DCIS, in the whole group (n = 120; p < 0.001) and in the hormone receptor (HR)-negative group (n = 60; p < 0.001). (B) However, within individual tumors, CXCL10 mRNA expression is not significantly different between DCIS and invasive components of the same tumor in all groups (n = 24, whole group; n = 12, HR-positive and H-negative group). (C) In comparison of DCIS (n = 60) with DCIS associated with invasive carcinoma (DCIS-INV) (n = 24), CXCL10 mRNA expression is significantly higher in DCIS-INV than in DCIS in the whole group (n = 84; p = 0.011) and in HR-negative group (n = 42; p = 0.020). *Statistically significant. The graphs were generated using SPSS version 25.0 for Windows (IBM Corp., Armonk, NY, USA).