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. 2021 Jun 14;46(11):1950–1957. doi: 10.1038/s41386-021-01046-x

Fig. 2. Chemogenetic activation of hypothalamic (PVN) oxytocin-containing neurons reduces alcohol consumption.

Fig. 2

A Individual and B group data showing that chemogenetic activation of PVNOT+ neurons reduced alcohol consumption in Oxt-IRES-Cre mice treated with active (AAV8-hSyn-DIO-hM3Dq-mCherry) virus. C, D Systemic CNO (3 mg/kg) administration did not alter alcohol drinking in Oxt-IRES-Cre mice harboring control (AAV8-hSyn-DIO-mCherry) virus. E, F Systemic administration of OT (1 mg/kg) decreased alcohol consumption compared to vehicle (saline) in Oxt-IRES-Cre mice. Values (panels B, D, F) are mean ± s.e.m. (N = 9–12/group); *p < 0.05 vs. saline.