Fig. 3. The brain-penetrant oxytocin receptor antagonist, L-368,899, reverses decreased alcohol intake following chemogenetic activation of PVN^OT+ neurons.

A In mice expressing the excitatory DREADD, CNO-induced activation of PVN^OT+ neurons decreased alcohol consumption compared to vehicle and pretreatment with L-368,899 (10 mg/kg) reversed this effect. B No effect was observed in animals treated with control virus. Values are mean ± s.e.m. (N = 5–7/group); *p < 0.05 vs. saline.