Table 3.
Demographic, clinical, and laboratory values in 238,321 hemodialysis patients according to dialyzer type in the Japanese classification.
| I | II | III | IV | V | P value | |
|---|---|---|---|---|---|---|
| n (%) | 2,255 (1.0) | 2,322 (1.0) | 5,730 (2.4) | 177,251 (74.3) | 50,763 (21.3) | |
| Age (years) | 74.8 ± 10.8 | 74.2 ± 11.4 | 69.2 ± 12.4 | 67.2 ± 12.3 | 62.6 ± 12.4 | <0.0001 |
| Sex (% female) | 53.3 | 49.6 | 41.4 | 39.0 | 31.0 | <0.0001 |
| Dialysis duration (years) | 3 [1–6] | 3 [1–7] | 5 [2–9] | 6 [3–10] | 7 [4–13] | <0.0001 |
| Presence of DM (%) | 50.9 | 47.8 | 46.2 | 44.5 | 39.4 | <0.0001 |
| Comorbid CVD (%) | 35.1 | 32.3 | 27.4 | 27.6 | 23.0 | <0.0001 |
| Coronary artery disease | 10.6 | 9.6 | 8.9 | 8.4 | 7.3 | |
| Ischemic stroke | 23.1 | 19.8 | 16.3 | 16.3 | 12.8 | |
| Hemorrhagic stroke | 6.3 | 7.0 | 5.0 | 5.4 | 4.5 | |
| Limb amputation | 3.6 | 3.9 | 3.4 | 3.2 | 2.9 | |
| BMI (kg/m2) | 19.9 ± 3.6 | 20.1 ± 3.5 | 20.9 ± 3.5 | 21.2 ± 3.6 | 21.8 ± 3.8 | <0.0001 |
| Hemoglobin (g/dL) | 10.0 ± 1.4 | 10.1 ± 1.4 | 10.3 ± 1.3 | 10.5 ± 1.3 | 10.6 ± 1.2 | <0.0001 |
| Serum albumin (g/dL) | 3.4 ± 0.5 | 3.4 ± 0.5 | 3.6 ± 0.4 | 3.7 ± 0.4 | 3.7 ± 0.4 | <0.0001 |
| Calcium (mg/dL) | 8.6 ± 0.9 | 8.7 ± 0.9 | 8.8 ± 0.8 | 8.9 ± 0.8 | 9.0 ± 0.8 | <0.0001 |
| Phosphate (mg/dL) | 4.9 ± 1.6 | 4.9 ± 1.5 | 5.2 ± 1.5 | 5.2 ± 1.4 | 5.4 ± 1.5 | <0.0001 |
| Intact PTH (pg/mL) | 114 [55–197] | 108 [57–191] | 119 [59–206] | 114 [57–195] | 122 [64–204] | <0.0001 |
| β2-microglobulin, (mg/L) | 29.0 ± 11.3 | 28.2 ± 10.1 | 27.7 ± 7.7 | 26.6 ± 7.0 | 26.9 ± 6.8 | <0.0001 |
| C-reactive protein (mg/dL) | 0.2 [0.1–0.8] | 0.2 [0.1–0.7] | 0.1 [0.1–0.5] | 0.1 [0.1–0.4] | 0.1 [0.1–0.3] | <0.0001 |
| Kt/V | 1.27 ± 0.29 | 1.30 ± 0.29 | 1.40 ± 0.28 | 1.43 ± 0.28 | 1.45 ± 0.28 | <0.0001 |
| nPCR (g/kg/day) | 0.79 ± 0.20 | 0.79 ± 0.18 | 0.84 ± 0.19 | 0.86 ± 0.18 | 0.89 ± 0.18 | <0.0001 |
| %CGR (%) | 71.6 ± 29.8 | 72.4 ± 29.7 | 87.3 ± 30.0 | 91.9 ± 28.8 | 99.8 ± 26.2 | <0.0001 |
| Mortality rate (/person-years) | 0.22 | 0.20 | 0.11 | 0.09 | 0.06 | <0.0001 |
%CGR, percent creatinine generation rate; CVD, cardiovascular disease; DM, diabetes mellitus; nPCR, normalized protein catabolic rate; PTH, parathyroid hormone.