Fig. 4.

In vivo tumor accumulation and mild PTT-defeated tumor hypoxia via H_H-Ti₃C₂-PEG NSs. (a) Blood circulation of H_H-Ti₃C₂-PEG NSs post i. v. injection. (b) PA imaging of H_H-Ti₃C₂-PEG NSs. (c) In vivo PA imaging of 4T1 tumor-bearing mice. (d) Time-dependent tumor PA signals at 800 nm based on PA imaging data in (c). (e) Biodistribution of H_H-Ti₃C₂-PEG NSs in mice after 12 h by i. v. injection. (f) IR thermal images of 4T1 tumors under the 1064 nm laser irradiation. (g) Tumor slices staining of different treatments. H_H-Ti₃C₂–PEG NSs: 20 mg ▪ kg⁻¹; NIR laser: 1064 nm, < 1W ▪ cm⁻², 15 min (n = 3 biologically independent mice). Data are presented as mean values ± SD.