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. 2021 Sep 9;7:73. doi: 10.1038/s41522-021-00243-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — (1) Burn wounds typically contain BWE which facilitates the initial inoculation and reversible attachment by planktonic pathogens. (2) Bacteria begin to produce ECM and form microcolonies during the process of irreversible attachment (3) During the maturation stage, the biofilm grows in size and structural complexity. (4) The mature biofilm enters the dispersal stage, releasing the planktonic cells from the ECM which can then colonize new sites within the wound. Created with BioRender.com.