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. 2021 Sep 9;11:17898. doi: 10.1038/s41598-021-95738-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of a live and pasteurized A. muciniphila on study's genes in the liver of normal mice. Mice were gavaged with a live and pasteurized A. muciniphila (10⁹ CFU) for 5 weeks. (A) Histopathology of eWAT of ND-fed mice. (4 samples per group). Scale bar is 50 µm. The mRNA expression of (B) inflammation-related genes (e.g. tlr-4, tnf-α, and il-6) and (C) lipid metabolism-related genes (e.g. ppar-α and tgf-β) in the eWAT of ND-fed mice. *, **, *** 'P < 0.05, P < 0. 01, and P < 0. 001 were considered statistically significant, respectively. C: normal diet + PBS, Am: normal diet + A. muciniphila (10⁹ CFU), PAm: normal diet + pasteurized A. muciniphila (10⁹ CFU).