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. 2021 Sep 9;7:114. doi: 10.1038/s41523-021-00320-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Boxplots showing the expression levels of DNA-PKcs by IHC according to “core basal status”. High expression of DNA-PKcs is associated with the core basal IHC phenotype (p-value < 0.001). Core basal is defined as ER-, PR-, Her2- and [EGFR + or CK5 + ]. The median (center bar), and the third and first quartiles (upper and lower edges, respectively) are shown. b Boxplots showing the expression levels of DNA-PKcs by IHC according to “sTILs” and “CD8 + iTILs” categories. High expression of DNA-PKcs is associated with high expression of sTILs and high expression of CD8 + iTILs. The median (center bar), and the third and first quartiles (upper and lower edges, respectively) are shown. c Kaplan–Meier curves for BCSS in the BC Cancer series according to DNA-PKcs IHC expression status. d Kaplan–Meier curves for BCSS stratified according to core basal status and DNA-PKcs IHC expression. Core basal tumors with high DNA-PKcs expression are associated with the worst BCSS. Abbreviations: IHC immunohistochemistry, sTILs stromal tumor-infiltrating lymphocytes, iTILs intraepithelial tumor-infiltrating lymphocytes, BCSS breast cancer-specific survival.