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. 2021 Sep 9;11:17863. doi: 10.1038/s41598-021-97480-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Kaplan Meier curves documenting CSS analysis concerning several selected variables. All death are showed in (A). There is a significantly worse survival in proximally situated tumors (B), advanced stage tumors (C), MMR-proficient tumors (H), CK7 + tumors using positivity cut-off on 10% (E) as well as on 1% (F). Using higher cut-off, the P-value is lower despite lower number of CK7 + cases (see discussion). Histopathological grade (D) is borderline insignificant despite visible trend in the curves. CK20 status (G) has no influence on survival.