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. 2021 Sep 9;11:17863. doi: 10.1038/s41598-021-97480-4

Table 1.

Summarizing of the distribution of CRCs according the cytokeratin profile and all studied variables; including p values of X-square test.

CK7-CK20- CK7-CK20 +  CK7 + CK20- CK7 + CK20 +  Total
Age group
 < 50 4 (25%) 10 (62.5%) 2 (12.5%) 0 (0%) 16 (100%)
50–59 4 (9.8%) 35 (81.4%) 2 (4.7%) 2 (4.7%) 43 (100%)
60–69 24 (24.5%) 69 (70.4%) 3 (3.1%) 2 (2%) 98 (100%)
70–79 16 (18.4%) 67 (77%) 3 (3.4%) 1 (1.1%) 87 (100%)
80 +  12 (21.8%) 40 (72.7%) 0 (0%) 3 (5.5%) 55 (100%)
X-squared = 14.375, df = 12, P-value = 0.277
Sex
F 28 (21%) 95 (71.5%) 6 (4.5%) 4 (3%) 133 (100%)
M 32 (19.2%) 127 (76%) 4 (2.4%) 4 (2.4%) 167 (100%)
X-squared = 1.518, df = 3, P-value = 0.678
UICC stage
I + II 31 (20.3%) 113 (73.9%) 4 (2.6%) 5 (3.3%) 153 (100%)
III + IV 29 (19.7%) 109 (74.1%) 6 (4.1%) 3 (2%) 147 (100%)
X-squared = 0.919, df = 3, P-value = 0.820
Situs
Cecum 8 (18.6%) 30 (69.8%) 3 (7%) 2 (4.7%) 43 (100%)
Ascendens 11 (30.6%) 20 (55.6%) 3 (8.3%) 2 (5.6%) 36 (100%)
Hepatic flexure 6 (42.9%) 8 (57.1%) 0 (0%) 0 (0%) 14 (100%)
Transversum 4 (28.6%) 10 (71.4%) 0 (0%) 0 (0%) 14 (100%)
Lienal flexure 4 (40%) 5 (50%) 0 (0%) 1 (10%) 10 (100%)
Descendens 3 (25%) 7 (58.3%) 2 (16.7%) 0 (0%) 12 (100%)
Sigmoideum 10 (14.9%) 56 (83.6%) 1 (1.5%) 0 (0%) 67 (100%)
Rectosigmoideum 2 (8%) 23 (92%) 0 (0%) 0 (0%) 25 (100%)
Rectum 11 (14.5%) 61 (80.3%) 1 (1.3%) 3 (3.9%) 76 (100%)
Multiple 1 (33.3%) 2 (66.7%) 0 (0%) 0 (0%) 3 (100%)
X-squared = 40.762, df = 27, P-value = 0.043
MMR
Deficient 12 (46.2%) 12 (46.2%) 2 (7.7%) 0 (0%) 26 (100%)
Proficient 43 (15.7%) 205 (74.8%) 13 (4.7%) 13 (4.7%) 274 (100%)
X-squared = 15.101, df = 3, P-value = 0.002
Grade
Low grade (1 + 2) 44 (20%) 164 (77%) 7 (3%) 2 (1%) 217 (100%)
High grade (3) 16 (23.2%) 47 (68.1%) 1 (1.4%) 5 (7.2%) 69 (100%)
X-squared = 9.721, df = 3, P-value = 0.021
Morphology
Mucinous + signet ring 2 (10.5%) 15 (78.9%) 1 (5.3%) 1 (5.3%) 19 (100%)
NOS 58 (20.6%) 207 (73.7%) 9 (3.2%) 7 (2.5%) 281 (100%)
X-squared = 1.716, df = 3, P-value = 0.633
5 years survival
No 17 (15.7%) 79 (73.1%) 7 (6.5%) 5 (4.6%) 108 (100%)
Yes 41 (22.8%) 134 (74.4%) 3 (1.7%) 2 (1.1%) 180 (100%)
X-squared = 9.620, df = 3, P-value = 0.022