Fig. 3. Timing of somatic events in triple-negative breast cancer (TNBC; N = 7).

a The diagram, left, of tumor evolution in the TNBC subtype shows the approximate timing of genomic alterations with respect to the cancer’s lifetime. b The timing of mutations and copy number events is shown as bars indicating whether the events are clonal or subclonal. Clonal mutations and chromosome-arm events are further designated as early or late with respect to whole-genome doubling (WGD). The number of samples harboring mutations and copy number alterations (CNAs, pre-GD and post-GD) is indicated on the right side of the bars. c Pie charts show the percentage of mutations for each signature, averaged across the TNBC cohort. Only genes that were mutated in Cancer Gene Census or canonical signaling pathways in the cohort are shown. AMP: amplification; DEL: deletion.