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. 2021 Sep 9;4:1052. doi: 10.1038/s42003-021-02597-x

Fig. 5. Indel mutational signatures (IDs) with homologous recombination deficiency (HRD) and whole-genome doubling (WGD).

Fig. 5

a Heatmap of the cosine similarity results for the de novo IDs (y-axis), coded by color. In the scale bar, the cosine similarity (range 0–1) represents the extent of similarity to a particular signature of COSMIC (x-axis). Among the 17 COSMIC IDs, the signatures associated with the double-strand repair by nonhomologous end-joining were the most similar mutational signatures detected in the Taiwanese population (dark red), while other signatures are of unknown cause in COSMIC or dissimilar. b The mutational spectrum of de novo signature ID2 and COSMIC signatures ID6 and ID8. c Box plots indicate the contribution of de novo signature ID2 (y-axis) across HRD and non-HRD tumors (x-axis). d Box plots indicate the contribution of de novo signature ID2 (y-axis) across WGD and non-WGD tumors (x-axis). One-tailed Mann–Whitney U tests were performed to calculate the p-values for the comparison of medians in c and d. Overall, 116 breast cancer samples were used to perform analyses in a–d.