Table 4.

Schizophrenia case-control analysis of neurodevelopmental disorders variants.

NDD variant set (N variants)	Schizophrenia case-control analysis
	Case rate (N variants)	Control rate (N variants)	P	Odds ratio (95% CI)
Primary variant set (7979)	0.0044 (18)	0.0023 (13)	0.036	1.90 (0.94, 3.95)
Comparator variant set (47,630)	0.095 (389)	0.097 (553)	0.42	1.01 (0.89, 1.15)

Firth’s penalised logistic regression models were used to evaluate the burden of NDD variants in 4,070 schizophrenia cases and 5,712 controls. As this analysis included indels, the number of variants included in the NDD primary and comparator variant sets differ to that presented in Table 3. P-values are uncorrected and one-tailed. NDD neurodevelopmental disorders, CI confidence interval.