Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 9;11:17928. doi: 10.1038/s41598-021-96986-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

T1% period in immunized mice after challenge with Pb-PvCSP transgenic sporozoites. Groups of six C57BL/6 mice were s.c. immunized with the vaccine formulations in the presence of Poly (I:C) or Montanide adjuvants, following the scheme shown in Table 1. Upper panel: Immunized mice were challenged 14 days after the third dose with 2,000 Pb-PvCSPVK210 sporozoites. Percent protection to reach 1% parasitemia (a, b) and follow-up analysis of parasitemia at days 4, 5 and 6 after challenge (c, d) is shown. Middle panel: Immunized mice were challenged 14 days after the third dose with 2,000 Pb-PvCSPVK247 sporozoites. Percent protection to reach 1% parasitemia (e, f) and follow-up analysis of parasitemia at days 4, 5 and 6 after challenge (g, h) is shown. Lower panel: Immunized mice were challenged 14 days after the third dose with 2000 spz of the new chimeric Pb-PvCSP-like G10 parasite. Percent protection to reach 1% parasitemia (i, j) and follow-up analysis of parasitemia at days 4, 5 and 6 after challenge (k, l) is shown. Significant differences in T1% periods (see Table 2) were analyzed by applying the log-rank (Mantel-Cox) test.

T1% period in immunized mice after challenge with Pb-PvCSP transgenic sporozoites. Groups of six C57BL/6 mice were s.c. immunized with the vaccine formulations in the presence of Poly (I:C) or Montanide adjuvants, following the scheme shown in Table 1. Upper panel: Immunized mice were challenged 14 days after the third dose with 2,000 Pb-PvCSPVK210 sporozoites. Percent protection to reach 1% parasitemia (a, b) and follow-up analysis of parasitemia at days 4, 5 and 6 after challenge (c, d) is shown. Middle panel: Immunized mice were challenged 14 days after the third dose with 2,000 Pb-PvCSPVK247 sporozoites. Percent protection to reach 1% parasitemia (e, f) and follow-up analysis of parasitemia at days 4, 5 and 6 after challenge (g, h) is shown. Lower panel: Immunized mice were challenged 14 days after the third dose with 2000 spz of the new chimeric Pb-PvCSP-like G10 parasite. Percent protection to reach 1% parasitemia (i, j) and follow-up analysis of parasitemia at days 4, 5 and 6 after challenge (k, l) is shown. Significant differences in T1% periods (see Table 2) were analyzed by applying the log-rank (Mantel-Cox) test.