Fig. 5.

Liver macrophage proliferation is impaired in Il6r^Mye-KO mice after PHx. A Liver-to-body weight ratios of Il6r^f/f and Il6r^Mye-KO mice post-PHx. B Immunofluorescence analysis of liver tissue sections from Il6r^f/f and Il6r^Mye-KO mice subjected to PHx (n = 6/group). Liver tissues were collected 40 h, 48 h, and 72 h after PHx and stained with antibodies targeting IBA1 (green) and BrdU (red). BrdU was injected 2 h before sacrifice. Arrowheads represent proliferating KCs. The quantification of hepatocyte and KC proliferation from panel B is shown in panels (C) and (D). E Immunofluorescence analysis of liver tissue sections from Il6r^f/f and Il6r^Mye-KO mice 48 h and 72 h after PHx staining with anti-F4/80 and TUNEL antibodies. The values are expressed as the mean ± SEM. *P < 0.05