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. 2021 Mar 3;46(11):2011–2020. doi: 10.1038/s41386-021-00985-9

Fig. 5. Oxcarbazepine and Huperzine A increase resistance to 6 Hz- and PTZ-induced seizures in RL/+ mutants.

Fig. 5

A OXC significantly increases resistance to 6 Hz-induced seizures in the RL/+ mutants. N = 9–13/group; Kruskal–Wallis test followed by Dunn’s multiple comparisons test. B OXC (50 mg/kg) significantly increases the latency to PTZ-induced GTCS in RL/+ mutants and WT littermates; however, the number of RL/+ mutants exhibiting a GTCS was comparable to vehicle-treated mutants. N = 8–9/group; log-rank (Mantel–Cox) test. C Hup A (1 mg/kg) confers robust protection against 6 Hz-induced seizures in RL/+ mutants. N = 9–10/group; Friedman’s test. D Hup A (1 mg/kg) significantly increased the latency to PTZ-induced GTCS in RL/+ mutants and WT littermates and reduced the number of mutants and WT littermates that exhibited a GTCS. N = 7–8/group. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001. Data are presented as mean ± SEM.