Figure 1.

Chemical synthesis and characterization of PLGA-PEG nanoparticles. (A) Illustrative chemical synthesis of PLGA-PEG-COOH and PLGA-PEG-mannose copolymers. (B) Schematic illustration for PFCE/Oil/Water double-emulsion and solvent-evaporation method used to produce PLGA-PEG, PLGA-PEG-mannosamine, or PLGA-PEG-FITC nanoparticles. Scanning Electron Microscopy (SEM) of PLGA-PFCE nanoparticles. (C) Scanning electron microscopy (SEM) image of PFCE encapsulatin PLGA NPs. (D) ¹⁹F-NMR spectrum of PFCE encapsulated PLGA-PEG-FITC-mannose NPs in CDCl3 d in ppm: −75.65 (3F, CF₃COOH); −89.50 (20F, C₁₀F₂₀O₅).