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Smoking affects the activity of eNOS by direct or indirect action (Red arrow: point of action). Inhibit GTPCH and reduce the synthesis of BH4; Promote the conversion of BH4 to BH2 through oxidative stress; Inhibit DHFR and reduce the conversion of BH2 to BH4;, ⑤ Prevent the combination of BH4 and eNOS to form a stable dimer; ⑥ Inhibit the conversion of L-Arg to NO; ⑦ Inhibit the activity of eNOS; ⑧ Promote the dissociation of Zn2+ from the dimer.
