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. 2021 Aug 27;8:704106. doi: 10.3389/fcvm.2021.704106

Table 2.

Advantages and limitations of mice and rabbits in animal models of ASO.

Species Mice Rabbits References
Advantages Low cost (relatively low cost of animals, low cost of intervention research) Easy to obtain, breed and raise Space requirements for CSE interventions are relatively small Easy to genetic modification Organizational availability is relatively large
Easy to obtain, breed and raise Translational medicine research
Relatively easy technical operation
(140143)
Limitations Less organizational availability Technical difficulties Wild-type relative anti-atherosclerosis Relatively high costs (relatively high animal costs, high intervention research costs)
Space requirements for cigarette smoke interventions are relatively large
ASO Animal models of genetic modification of multiple key genes (e.g. ApoE-/-, LDL-/-, etc.) Lipid metabolism is quite different from human ApoE -/- Fbn1 C1039G+/- mice can mimic human atherosclerotic plaque rupture and bleeding more closely WHHL rabbits
Unique lipid metabolism, much closer to human
The process of atherosclerosis is closer to that of humans
(144148)

ASO, Arteriosclerosis; CSE, Cigarette smoke extract; WHHL, Watanabe heritable hyperlipidemic.