Table 2.
Species | Mice | Rabbits | References |
---|---|---|---|
Advantages | Low cost (relatively low cost of animals, low cost of intervention research) Easy to obtain, breed and raise Space requirements for CSE interventions are relatively small Easy to genetic modification | Organizational availability is relatively large Easy to obtain, breed and raise Translational medicine research Relatively easy technical operation |
(140–143) |
Limitations | Less organizational availability Technical difficulties Wild-type relative anti-atherosclerosis | Relatively high costs (relatively high animal costs, high intervention research costs) Space requirements for cigarette smoke interventions are relatively large |
|
ASO | Animal models of genetic modification of multiple key genes (e.g. ApoE-/-, LDL-/-, etc.) Lipid metabolism is quite different from human ApoE -/- Fbn1 C1039G+/- mice can mimic human atherosclerotic plaque rupture and bleeding more closely | WHHL rabbits Unique lipid metabolism, much closer to human The process of atherosclerosis is closer to that of humans |
(144–148) |
ASO, Arteriosclerosis; CSE, Cigarette smoke extract; WHHL, Watanabe heritable hyperlipidemic.