Table 4.

Odds ratio (OR) and 95% confidence intervals (CIs) for the association between APOL1 risk genotype and CKD.

APOL RRA	Model 1, OR	Model 2, OR	Model 3, OR	Model 4, OR
	(95% CI)	(95% CI)	(95% CI)	(95% CI)
1	2.07 (0.92–4.66)	2.03 (0.89–4.63)	2.03 (0.89–4.63)	4.42 (1.49–13.15)
2	5 (2.17–11.547)	4.96 (2.15–11.46)	4.96 (2.15–11.46)	12.6 (3.89–40.8)

Multivariate logistic regression with stepwise and forward model selection was used to predict the risk for CKD. The explanatory variable is number of APOL1 risk alleles: model 1, adjusted for age and sex; model 2, further adjusted for JC and BK viruria; model 3 further adjusted for HIV viremia, model 4 further adjusted for APOL1 RRA^* HIV interaction.