Table 6.

Predictions on MRS detected changes over time in ALS patients taking Riluzole and Edaravone, both of which target enhancing astrocytic glutamate uptake and therefore lowering synaptic and extracellular glutamate levels, relative to ALS patients not taking these drugs.

Example	Class of drugs	Impact to synaptic glutamate	Impact to Glx/NAA	Impact to GABA/Glx	Impact to NAA
Riluzole	Benzothiazoles	Decrease	Reduced rate of increase	Reduced rate of decrease	Reduced rate of decrease
Edaravone	Antioxidants	Decrease	reduced rate of increase	Reduced rate of decrease	Reduced rate of decrease