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. 2021 Aug;10(8):2197–2209. doi: 10.21037/tp-20-226

Table 1. Summary of maternal hyperoxygenation in congenital heart disease.

Reference Diagnosis Oxygen delivery Protocol Goals
Szwast et al. [2010] HLHS with or without RAS/IAS Acute 60% eFiO2, assessed after 10 min Assess for fetal pulmonary vasculopathy
Enzensberger et al. [2016] HLH with or without RAS/IAS Acute 60% eFiO2, assessed after 10 min Assess for fetal pulmonary vasculopathy
Kohl et al. [2010] Hypoplastic heart structures Chronic 50–60% eFiO2, 3×4 hours of MH/day Improve cardiac structural growth
Kohl et al. [2011] Foramen ovale closure, aortic isthmus hypoplasia, turbulent distal arch flow Chronic 45% eFiO2, 3×4 hours of MH/day Improve aortic isthmus dimensions
Zeng et al. [2016] Isolated coarctation Chronic 45% eFiO2, 2×3 hours of MH/day Improve left-sided cardiac structural growth
Zeng et al. [2017] Isolated coarctation Chronic 45% eFiO2, 2×3 hours of MH/day Improve left-sided cardiac structural growth
Lara et al. [2016] LHH Chronic 50% eFiO2, >8 hours of MH/day Improve left-sided cardiac structural growth
Channing et al. [2015] Fetal atrial septum aneurysm with small LV Acute 60% eFiO2, assessed after 10 min Improve left-heart filling
Porayette et al. [2016] CHD Acute 70% eFiO2, assessed after 10 min Validate CMR in fetuses with CHD
Borik et al. [2015] Borderline LVH with retrograde flow across the aortic isthmus Acute 70% eFiO2, assessed after 20 min Fetal circulatory assessment in CHD
Szwast et al. [2018] HLHS variants Acute 60% eFiO2, assessed after 10 min Assess cerebrovascular response
Hogan et al. [2020] LSOL, RSOL, d-TGA Acute 60% eFiO2, assessed after 10 min Assess cerebrovascular response
You et al. [2020] CHD Acute 70% eFiO2, assessed for 6 min Identify cerebral oxygenation
Edwards et al. [2019] LHH Chronic 50% eFiO2, >8 hours of MH/day Improve fetal brain development

HLHS, hypoplastic left heart syndrome; RAS, restrictive atrial septum; IAS, intact atrial septum; HLH, hypoplastic left heart; LHH, left heart hypoplasia; LV, left ventricle; CHD, congenital heart disease; LSOL, left-sided obstructive lesion; RSOL, right-sided obstructive lesion; d-TGA, dextro-transposition of the great arteries; CMR, cardiac magnetic resonance; LVH, left ventricular hypoplasia; eFiO2, effective fraction of inspired oxygen.