· Diabetes mellitus or gestational diabetes |
· Suspected cardiac anomaly on obstetric ultrasound |
· Lupus or Sjogren’s syndrome with anti-SSA/anti-SSB antibodies |
· Fetal arrhythmia |
· Use of assisted reproduction technology |
· Extracardiac anomaly |
· Maternal infection during pregnancy (i.e., Rubella, Coxsackie, Parvovirus) |
· Chromosomal abnormality |
· Teratogen exposure |
· Increased NT (≥3 mm) |
· Phenylketonuria, uncontrolled |
· Fetal hydrops or pericardial effusion |
· Family history of congenital heart disease in 1st degree relative (mother/father/sibling of fetus) |
· Monochorionic twinning |
· Abnormal umbilical or placental venous anatomy |