Table 3.

Ongoing controlled trials of ECPR for out-of-hospital cardiac arrest

Title	Study design	Sample size	Brief description	Primary outcome(s)
Early initiation of extracorporeal life support in refractory OHCA (INCEPTION); NCT03101787	Multi-center randomized controlled trial	110	ECPR versus conventional CPR	30-day survival with favorable neurological status (CPC 1 or 2)
BC ECPR trial for out-of-hospital cardiac arrest; NCT02832752	Non-randomized, controlled parallel group trial (allocation based on region of treatment)	420	Incorporation of ECPR into regional medical system, compared to regions providing usual care	CPC status at hospital discharge
CPR, pre-hospital ECMO and early reperfusion (CHEER 3 Trial) for patients in refractory cardiac arrest to improve survival to hospital discharge	Single-center feasibility study	25	Implementation of pre-hospital ECPR	CPC status at hospital discharge
Pre-hospital ECMO in advanced resuscitation ion patients with refractory cardiac arrest (SUB30); NCT03700125	Single-center feasibility study	6	Implementation of a pre-hospital ECMO-capable cardiac arrest team	Proportion of patients successfully established with pre-hospital ECPR within 30 min of collapse

CPR cardiopulmonary resuscitation, ECPR extracorporeal cardiopulmonary resuscitation, ECMO extracorporeal membrane oxygenation, CPC cerebral performance status, OHCA out-of-hospital cardiac arrest