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. 2021 Aug 27;11:634219. doi: 10.3389/fonc.2021.634219

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Copyright © 2021 Noh, Lim, Lee, Cho, Lee, Roh, Kim, Lee, Park, Kim and Shin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Three-dimensional pseudocolored ratiometric two-photon microscopy images (Ch2/Ch1) of normal and cancer tissue using SE1. (A) Sectional images of SE1 in normal tissue. (B) Sectional images of SE1 in cancerous tissue. (C) Ratio value of each section at varying depths in normal tissue. (D) Ratio value of each section at varying depths in cancerous tissue. The red boxed area in panels (B, C) are enlarged to show images by depth. Maximum and minimum values are illustrated using error bars.