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. 2021 Aug 27;12:694046. doi: 10.3389/fendo.2021.694046

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Copyright © 2021 Henry, Thomas and Ross

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simulated cortisol profile for a patient [broken line] following thrice-daily hydrocortisone administration [10mg at 06:00, 5mg at 12:00 and 2.5mg at 18:00, shown as solid arrows]. The normal circadian rhythm of cortisol [solid line]. From Mah et al. (211). Weight‐related dosing, timing and monitoring hydrocortisone replacement therapy in patients with adrenal insufficiency. Clinical Endocrinology, 61(3), 367-375.