Table 1.
Pharmacokinetic parameters of caffeine following IV administration of 15 mg/kg caffeine in the presence and absence of 100 mg/kg rutaecarpine in rats. Each value represents the mean ± S.D. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
| Caffeine (IV) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | AUCINF (μg.h/mL) | Clearance (mL/h) | MRTinf (h) | T 1/2 (h) | Vss (mL) | |||||
| Control | 64.3 ± 2.3 | % of control | 56.1 ± 2.1 | % of control | 1.85 ± 0.16 | % of control | 1.28 ± 0.12 | % of control | 103.90 ± 11.49 | % of control |
| 3 h | 48.7 ± 5.5 | 76% | 74.6 ± 8.5 | 133% | 1.88 ± 0.28 | 102% | 2.91 ± 1.53 | 227% | 140.17 ± 23.84 | 135% |
| 6 h | 40.9 ± 4.1*** | 64% | 88.7 ± 8.9* | 158% | 1.70 ± 0.59 | 92% | 3.20 ± 2.06 | 250% | 149.10 ± 49.47 | 144% |
| 12 h | 23.5 ± 3.4**** | 37% | 155.7 ± 23.9*** | 278% | 0.52 ± 0.06** | 28% | 1.64 ± 1.08 | 128% | 79.55 ± 8.75 | 77% |