Table 2.
Pharmacokinetic parameters of caffeine following oral administration of 20 mg/kg caffeine in the presence and absence of 100 mg/kg rutaecarpine in rats. Each value represents the mean ± S.D. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
| Caffeine (oral) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | Cmax (μg/mL) | T 1/2 (h) | MRTinf (h) | AUCinf (μg.h/mL) | Tmax (h) | Cl/F (mL/h) | F (%) | ||||||
| Control | 19.5 ± 2.0 | % of control | 1.12 ± 0.15 | % of control | 2.34 ± 0.29 | % of control | 72.4 ± 10.0 | % of control | 0.8 ± 0.3 | % of control | 70.0 ± 10.0 | % of control | 81.1 ± 11.4 |
| Zero hour | 13.4 ± 3.1 | 69% | 0.62 ± 0.07*** | 55% | 2.63 ± 0.13 | 112% | 57.2 ± 10.2 | 79% | 2.0 ± 0.0**** | 250% | 89.3 ± 16.4 | 128% | 64.11 ± 11.77 |
| 3 h | 13.1 ± 0.6 | 67% | 0.61 ± 0.11*** | 54% | 1.27 ± 0.12**** | 54% | 26.9 ± 3.1**** | 37% | 0.5 ± 0.5 | 62.5% | 187.7 ± 22.5 | 268% | 39.8 ± 6.4** |
| 6 h | 10.5 ± 1.0** | 54% | 0.59 ± 0.16*** | 53% | 1.13 ± 0.23**** | 48% | 18.7 ± 5.6**** | 26% | 0.7 ± 0.3 | 87.5% | 287.4 ± 100.6 | 411% | 32.8 ± 10.2*** |
| 12 h | 12.9 ± 5.1* | 66% | 0.35 ± 0.13**** | 31% | 0.73 ± 0.17**** | 31% | 12.5 ± 4.1**** | 17% | 0.5 ± 0.0 | 62.5% | 434.8 ± 163.9* | 621% | 38.3 ± 13.6*** |