Table 3.

Pharmacokinetic parameters of paraxanthine after administration of 15 mg/kg caffeine intravenously in the. presence and absence of rutaecarpine in rats. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

Paraxanthine (IV caffeine)
Parameter	AUCINF (μg.h/mL)		Tmax (h)		MRTinf (h)		T 1/2 (h)		AUCm/AUCp
Control	21.571 ± 2.743	% of control	4.667 ± 1.15	% of control	5.03 ± 0.43	% of control	1.349 ± 0.09	% of control	0.74 ± 0.04	% of control
3 h	8.31 ± 0.72****	39%	2.67 ± 1.15*	57%	2.85 ± 0.28****	57%	0.47 ± 0.10****	35%	0.54 ± 0.03**	73%
6 h	6.17 ± 0.59****	29%	2.0 ± 0.00**	43%	2.57 ± 0.27****	51%	0.82 ± 0.07**	61%	0.51 ± 0.04**	69%
12 h	3.86 ± 1.30****	18%	1.0 ± 0.00***	21%	1.28 ± 0.212****	25%	0.49 ± 0.24****	37%	0.42 ± 0.13***	57%