Table 4.
Pharmacokinetic parameters of paraxanthine following oral administration of 20 mg/kg caffeine in the presence and absence of 100 mg/kg rutaecarpine in rats. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
| Paraxanthine (oral caffeine) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | Cmax (μg/mL) | T 1/2 (h) | MRTinf (h) | AUCinf (μg.h/mL) | Tmax (h) | AUCm/AUCp | ||||||
| Control | 2.8 ± 0.9 | % of control | 1.59 ± 0.28 | % of control | 5.06 ± 1.07 | % of control | 19.0 ± 6.6 | % of control | 4.00 ± 0.00 | % of control | 0.68 ± 0.06 | % of control |
| Zero hour | 3.3 ± 0.1 | 118% | 0.71 ± 0.04 | 45% | 5.10 ± 0.16 | 101% | 15.2 ± 1.2 | 80% | 6.00 ± 0.00**** | 150% | 0.67 ± 0.02 | 99% |
| 3 h | 2.1 ± 0.4 | 75% | 1.11 ± 0.56 | 70% | 3.03 ± 0.38* | 60% | 8.7 ± 2.6** | 46% | 2.00 ± 0.00**** | 50% | 0.65 ± 0.07 | 95% |
| 6 h | 1.9 ± 0.1 | 68% | 0.82 ± 0.36 | 52% | 2.16 ± 0.47*** | 43% | 5.0 ± 0.7*** | 26% | 2.00 ± 0.00**** | 50% | 0.56 ± 0.04 | 82% |
| 12 h | 3.2 ± 1.0 | 114% | 0.55 ± 0.39 | 35% | 1.57 ± 0.33*** | 31% | 6.5 ± 2.1*** | 34% | 1.33 ± 0.58**** | 33% | 0.74 ± 0.10 | 109% |