Table 5.
Pharmacokinetic parameters of theophylline after administration of 15 mg/kg caffeine intravenously in the presence and absence of rutaecarpine in rats. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
| Theophylline (IV caffeine) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | AUCINF (μg.h/mL) | Tmax (h) | MRTinf (h) | T 1/2 (h) | AUCm/AUCp | |||||
| Control | 29.412 ± 1.286 | % of control | 4.000 ± 0.00 | % of control | 4.34 ± 0.29 | % of control | 0.985 ± 0.12 | % of control | 0.81 ± 0.01 | % of control |
| 3 h | 17.532 ± 1.331**** | 60% | 2.000 ± 0.00* | 50% | 2.58 ± 0.20**** | 59% | 0.653 ± 0.14* | 66% | 0.74 ± 0.03 | 91% |
| 6 h | 16.181 ± 1.082**** | 55% | 1.000 ± 0.00** | 25% | 2.11 ± 0.19**** | 49% | 0.811 ± 0.17 | 83% | 0.76 ± 0.04 | 94% |
| 12 h | 10.169 ± 3.599**** | 34% | 1.000 ± 0.00*** | 25% | 1.04 ± 0.118**** | 24% | 0.384 ± 0.02*** | 39% | 0.72 ± 0.13 | 89% |