Table 6.
Pharmacokinetic parameters of theophylline following oral administration of 20 mg/kg caffeine in the presence and absence of 100 mg/kg rutaecarpine. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
| Theophylline (oral caffeine) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | Cmax (μg/mL) | T 1/2 (h) | MRTinf (h) | AUCinf (μg.h/mL) | Tmax (h) | AUCm/AUCp | ||||||
| Control | 6.6 ± 1.6 | % of control | 1.09 ± 0.10 | % of control | 4.37 ± 0.96 | % of control | 37.7 ± 6.6 | % of control | 3.33 ± 1.15 | % of control | 0.85 ± 0.06 | % of control |
| Zero hour | 8.5 ± 0.3 | 129% | 0.62 ± 0.07 | 57% | 4.77 ± 0.10 | 109% | 36.5 ± 0.5 | 97% | 6.00 ± 0.00**** | 180% | 0.89 ± 0.04 | 105% |
| 3 h | 6.4 ± 1.5 | 97% | 0.97 ± 0.15 | 89% | 2.48 ± 0.22*** | 57% | 20.7 ± 5.6*** | 55% | 2.00 ± 0.00* | 60% | 0.91 ± 0.05 | 108% |
| 6 h | 9.9 ± 0.9* | 150% | 0.73 ± 0.08** | 67% | 1.93 ± 0.22**** | 44% | 27.9 ± 2.2* | 74% | 2.00 ± 0.00* | 60% | 1.16 ± 0.15* | 137% |
| 12 h | 8.4 ± 1.6 | 127% | 0.37 ± 0.03**** | 34% | 1.21 ± 0.19**** | 28% | 15.3 ± 3.1**** | 41% | 1.00 ± 0.00**** | 30% | 1.10 ± 0.11 | 130% |