Table 7.
Pharmacokinetic parameters of theobromine after administration of 15 mg/kg caffeine intravenously in the presence and absence of rutaecarpine in rats. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
| Theobromine (IV caffeine) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | AUCINF (μg.h/mL) | Tmax (h) | MRTinf (h) | T 1/2 (h) | AUCm/AUCp | |||||
| Control | 17.1 ± 1.5 | % of control | 5.333 ± 1.15 | % of control | 5.13 ± 0.35 | % of control | 1.4 ± 0.18 | % of control | 0.68 ± 0.03 | % of control |
| 3 h | 6.9 ± 0.3**** | 40% | 2.7 ± 1.15* | 51% | 3.09 ± 0.23**** | 60% | 0.9 ± 0.30 | 64% | 0.50 ± 0.01** | 74% |
| 6 h | 8.7 ± 1.3**** | 51% | 2.0 ± 0.00** | 38% | 3.09 ± 0.56**** | 60% | 1.4 ± 0.57 | 100% | 0.60 ± 0.05 | 88% |
| 12 h | 4.6 ± 1.1**** | 27% | 1.0 ± 0.00*** | 19% | 1.45 ± 0.074**** | 28% | 0.7 ± 0.03 | 50% | 0.48 ± 0.09** | 71% |