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. 2021 Jun 11;8:368–380. doi: 10.1016/j.bioactmat.2021.06.003

Fig. 5.

Fig. 5

In vivo biodistribution and anti-inflammatory effect of Cur-TFNAs on acute gouty arthritis. (a) and (b) Joint swelling in mice (left ankle: PBS, right ankle: MSU + TFNAs/Cur/Cur-TFNAs/Colchicine; n = 4). Statistical analysis: *p < 0.05, **p < 0.01, and ***p < 0.001. (c) Photomicrographs stained by HE. Scale bars are 10 μm and 50 μm. (d) IVIS image of ankles treated with Cur and the Cur-TFNAs (left ankle: Cur, right ankle: Cur-TFNAs). (e) Thermal image of ankles.