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. 2021 Aug 27;12:711433. doi: 10.3389/fimmu.2021.711433

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Copyright © 2021 Xu, Chen, Hu and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunotherapeutic Significance of ICI Scores. (A) ICB-relevant genes (CD274, CTLA4, HAVCR2, IDO1, PDCD1, and PDCD1LG2) and inflammatory-related genes (CD8A, CXCL10, CXCL9, GZMA, GZMB, IFNG, PRF1, TBX2, and TNF) expressed in the high and low ICI score subgroups. Correlation between the ICI score with crucial immune checkpoint blockade genes. (B) Correlation analysis between immune checkpoint inhibitors (CD274, PDCD1, PDCD1LG2, CTLA4, HAVCR2, and IDO1) with the ICI score. (C) Correlation between the ICI score and CD274. (D) Correlation between the ICI score and CTLA4. (E) Correlation between the ICI score and HAVCR2. (F) Correlation between the ICI score and IDO1. (G) Correlation between the ICI score and PDCD1. (H) Correlation between the ICI score and PDCD1LG2. The asterisks represented the statistical p value (***P < 0.001), ns, No Significance.