Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 27;12:676813. doi: 10.3389/fphar.2021.676813

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Huang, Yuan, Liu, Liu, Wung and Chuang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Capsaicin plus each of four anticancer agents show synergistic effects on cell viability and induce necroptosis in HSC-3 and SAS cells. (A) Cells were cotreated with 200 μM capsaicin and each of the listed anticancer drugs for 48 h, and cell viability was evaluated by CCK-8. The combined effect of capsaicin and anticancer drugs was evaluated using a combination index (CI)-isobologram equation that allows quantitative determination of drug interactions, as described in the Materials and Methods. (B) Cells were co-treated with 200 μM capsaicin and each of the listed anticancer drugs for 48 h, and Western blot assays were used to examine the levels of specific proteins related to apoptosis, autophagy, necroptosis, and the DNA damage responses.