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. 2021 Aug 27;11:705562. doi: 10.3389/fonc.2021.705562

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Copyright © 2021 Leystra, Harvey, Kaunga, Hensley, Vanderveer, Devarajan and Clapper

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of cytokines involved in Th1, Th2, Th9, and Th17 signaling in nonneoplastic colon tissue from Apc^+/+-FCCC wild type (white; n=9), tumor-free Apc^+/Min-FCCC (light gray; n=13), and tumor-bearing Apc^+/Min-FCCC (dark gray; n=13) mice. Boxplots depict the cytokine concentration in media (pg/ml) normalized to mass of colon tissue (mg) cultured from each mouse. Outlying data points (>3rd quartile + 1.5 x interquartile range) are omitted; all data points are shown in Supplemental Figure 7. Fold change in median cytokine expression in tumor-bearing tumor-free = 0.4 – 0.9; Mann Whitney p≥0.06; p=1.00 after adjusting for multiple comparisons.