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. 2021 Aug 27;11:645177. doi: 10.3389/fonc.2021.645177

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Copyright © 2021 Li, Zhang and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interaction among imaging-guided techniques, treatment margins of tumor target, and organs at risk (OARs) based on the accuracy of imaging approaches. Decreasing volume around gross tumor volume (GTV, in red), clinical target volume (CTV, in orange), planning target volume (PTV, in blue), planning organ at risk volume (PRV, in green), and organs at risk (OARs, in yellow); distance changes between treatment margins and OARs in intensity-modulated radiation therapy (IMRT), image-guided radiation therapy (IGRT), and function imaging-guided IMRT. (A) Relations between distance (x-axis) of gross target and organ at risk. (B) Relations between the distance (x-axis) and TV dose escalation (y-axis). (C) Relations between the distance (x-axis) and OARs dose exposure (y-axis). (D) Relations between TV dose/OARs dose and therapeutic index.