TABLE 3.
Comparison of pharmacokinetic parameters of different type of metabolizers.
| PK parameter | IM (N = 47) | EM (N = 27) | PM (N = 13) | PM/EM ratio | PM/EM pValue | PM/EM 95%CI | PM/IM ratio | PM/IM 95%CI | PM/IM pValue |
|---|---|---|---|---|---|---|---|---|---|
| Ln AUC0-t (h*ng/ml) | 478.0 | 347.8 | 619.7 | 1.78 | <0.001 | 145–218 | 1.30 | 107–157 | 0.007 |
| Ln AUC0-∞ (h*ng/ml) | 534.1 | 366.7 | 753.9 | 2.06 | <0.001 | 161–262 | 1.41 | 113–177 | 0.003 |
| Ln Cmax (ng/ml) | 12.5 | 11.9 | 13.5 | 1.13 | 0.124 | 97–133 | 1.08 | 93–125 | 0.319 |
The ANOVA was used in analysis. CI Confidence Interval. Cmax, maximum plasma concentration; AUC0-t, area under the plasma concentration-time curve from the time of administration up to the last time point with a measurable concentration post-dose; AUC0-∞, AUC extrapolated to infinity.