Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Comparison of CSS of different type of metabolizers.
| PK parameter | IM (N = 47) | EM (N = 27) | PM (N = 13) | PM/EM ratio | PM/EM 95%CI | PM/EM pValue | PM/IM ratio | PM/IM 95%CI | PM/IM pValue |
|---|---|---|---|---|---|---|---|---|---|
| Ln Cav, ss (ng/ml) | 17.8 | 12.2 | 25.1 | 2.06 | 161–262 | <0.001 | 1.41 | 113–177 | 0.003 |
| Ln Cmin, ss (ng/ml) | 13.8 | 8.7 | 20.7 | 2.39 | 180–317 | <0.001 | 1.51 | 116–196 | 0.003 |
The ANOVA was used in analysis. CI Confidence Interval. Cav, ss, average steady-state blood concentration; Css, min, minimum steady-state blood concentration.
