Figure 3.

Metabolic phenotyping revealed significant changes in the DKO mice. (A) The metabolic phenotyping protocol is shown. (B) Total body mass, percent lean mass, and percent fat mass measured by echo-MRI. (C) Daily food intake and daily water intake, adjusted for body weight. (D) Daily total energy expenditure and average respiratory exchange ratio. (E) Total average oxygen consumption and carbon dioxide production adjusted for bodyweight. (n = 5 control, 8 DKO mice). Data are shown as mean +/− SEM ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001, unpaired student t-test.