Fig. 1.

Extraction and modelling of a disconnectome. A. Simplified representation of the atlas-based tractogram connectivity of three brain regions i, j and k and their respective streamlines. A_t is the associated adjacency matrix of the atlas connectome, where each element A_t(i,j) represents the number of streamlines connecting the pair of regions (i,j). B. Overlapping of the atlas tractogram with the lesion mask. Streamlines passing through the lesion L are highlighted in red. C. Affected streamlines are isolated. A_c is the adjacency matrix of the affected streamlines, where each element A_c(I,j) represents the number of affected streamlines connecting the pair of regions (i,j) D. The brain graph representation where brain areas i, j and k are represented respectively by nodes V_i V_j and V_k and edges are weighted by the relative number of affected streamlines. The adjacency matrix of the remaining connectivity is defined as the relative difference between A_t and A_c. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)