Fig. 3.

Flow diagram showing the applicability conditions of the atlas-based disconnectome model, based on age, brain atrophy and brain segmentation quality estimated from MorphoBox (Schmitter et al., 2015). $\mathrm{f}\left(\mathrm{x}\right)$ is the 3% percentile of normative ranges. N_i: initial number of patients. N₀: number of patients discarded due to poor registration quality. N₁: number of patients discarded due to bad segmentation quality. N₂: number of patients younger than the age range covered by the tractography atlas, who are discarded due to abnormally low brain volume. N₃: number of patients inside the atlas age range discarded due to abnormally low brain volume. N₄: number of patients older than the age range covered by the tractography atlas, who are discarded due to abnormally low brain volume.