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Schematic of the phosphorylation (activation) and dephosphorylation (deactivation) mechanisms for NEPHRIN and NEPH1 in podocytes. In response to injury, HGF initiates the recovery process by phosphorylating NEPHRIN and NEPH1, which induces actin cytoskeleton reorganization leading to podocyte repair. To maintain homeostasis, subsequent dephosphorylation is mediated in a SHP2-dependent manner.
