TABLE 4.
Summary of BIS parameters.
| BIS parameters | Elderly 0.2 mg/kg | Elderly 0.3 mg/kg | Elderly 0.4 mg/kg | Non-elderly 0.4 mg/kg | Total | |
|---|---|---|---|---|---|---|
| (N = 8) | (N = 8) | (N = 8) | (N = 8) | (N = 32) | ||
| BISpeak | Mean (SD) | 60.1 (12.9) | 58.5 (3.82) | 58.1 (7.14) | 48.5 (6.12) | 56.3 (9.06) |
| — | Median | 61.5 | 59.5 | 58.0 | 47.5 | 56.5 |
| — | Min, Max | 43, 77 | 53, 63 | 48, 69 | 42, 61 | 42, 77 |
| TBISpeak, min | Mean (SD) | 4.13 (2.10) | 4.75 (2.05) | 3.88 (1.46) | 3.25 (0.46) | 4.00 (1.67) |
| — | Median | 3 | 4.5 | 3.5 | 3 | 3 |
| — | Min, Max | 3.00, 9.00 | 2.00, 7.00 | 2.00, 6.00 | 3.00, 4.00 | 2.00, 9.00 |
| BIS AUC0-t | Mean (SD) | 5248.6 (238.9) | 5067.7 (207.6) | 5018.3 (315.8) | 5090.1 (190.6) | 5106.2 (247.0) |
| — | Median | 5357.8 | 5093.0 | 5020.0 | 5013.8 | 5109.5 |
| — | Min, Max | 4897.5, 5471.5 | 4781.5, 5354.0 | 4515.0, 5432.0 | 4877.5, 5381.5 | 4515.0, 5471.5 |
| BIS AUC0–30 min | Mean (SD) | 2444.9 (158.5) | 2254.1 (107.7) | 2232.6 (188.1) | 2202.3 (156.8) | 2283.5 (176.5) |
| — | Median | 2494.8 | 2220.3 | 2176.8 | 2179.0 | 2234.5 |
| — | Min, Max | 2196.0, 2623.0 | 2,136.0, 2,422.0 | 2038.0, 2513.5 | 2028.0, 2512.5 | 2028.0, 2623.0 |
BISpeak: BIS peak value (the lowest BIS value); TBISpeak: time to BIS peak; BIS AUC0-t: area under the BIS curve from zero to last collection time; BIS AUC0–30 min: area under the BIS curve from zero to 30 min.