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. 2021 Aug 27;15:660837. doi: 10.3389/fncir.2021.660837

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Copyright © 2021 Vakilna, Tang, Wheeler and Brewer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Feed-forward (FF) and feedback (FB) units between the subregions. (A) Interregional axons by subregions that they connect. Most tunnels were populated by a single axon. Two or three axon units were also detected. Spike sorting and subsequent determination of direction of propagation yield substantial numbers of feedback units in each subregion (n = 8 arrays). (B) EC-DG tunnels predominantly contain feed-forward axons, implying that the direction of information flow is predominantly feed-forward, whereas DG-CA3 and CA3-CA1 contain significantly more tunnels with feedback axons or bidirectional (containing both FF and FB units). (C) Slower feedback velocities of spike propagation than feed-forward axons by 2-way ANOVA with Tukey HSD subtests of the confidence interval overlap. p-values above bars are for the feed-forward vs. feedback comparison. Bars are mean and 95% confidence intervals of conduction delays. Corresponding conduction velocities are also indicated above bars for the 0.2-mm electrode spacing. N = 10 arrays.