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. 2021 Aug 27;15:660837. doi: 10.3389/fncir.2021.660837

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Copyright © 2021 Vakilna, Tang, Wheeler and Brewer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interspike intervals (ISIs) followed log-log distributions (linear in log-log space). (A) ISIs as complementary cumulative probabilities in feed-forward axons. More spikes at shorter time intervals are from fastest spiking in EC-DG axons. Longer ISIs from slowest spiking axons are in DG-CA3. (B) ISIs in feedback axons. Fastest spiking in axons from DG back to EC. (C) Subregional ISIs are shortest (fastest) in the CA1 subregion. R² > 0.99 for all fits. N = 10 arrays. (D) Feed-forward axon ISI slopes of which EC-DG is 27% faster than DG-CA3 and each of the others. The median ISI (p = 0.5) for EC-DG from A occurred earliest at 25.6 ms for EC-DG. (E) Feedback axon slopes of ISI distributions with DG back to EC significantly faster than the others and shortest median. (F) Subregion neuron ISI slopes with CA1 fastest. P-values calculated using ANCOVA followed by Tukey-HSD. The error bars represent the 95% confidence intervals obtained by ANCOVA.